We published an in-depth review of the role of autophagy in metastasis in Oncogene. This timely review covers roles for autophagy in tumor cell migration and invasion, cancer stem cells, epithelial to mesenchymal transition, resistance to anoikis, tumor cell dormancy, anti-tumor immune surveillance and other emerging functions for autophagy in metastasis.
UChicagoBSD Womens’ Crush Wednesday after last week’s graduation ceremony during which Marina Sharifi (front left), Michelle Beaton (back right), Aparajita Hoskote Chourasia (front right), Lauren Olson (back left) and Erin Mowers (back middle) officially became Ph.D.s!
Our paper “Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3” is published on-line in Cell Reports.
Some media coverage of our work!
Stopping cancer in its tracks by disrupting cellular housekeeping
May 5th 2016
Erin successfully defends her Ph.D. thesis May 5th! Congrats Erin!
Maya presents her data at AACR in New Orleans.
Also attending AACR in New Orleans are (below, from left to right): Maya Zafrir Springer (current Macleod Lab graduate student), Stephen Tait (fellow mitochondriac from the University of Glasgow), Ben Spike (former Macleod Lab graduate student and currently Assistant Professor at the Huntsman Cancer Institute) and Huiping Liu (former Macleod Lab graduate student and currently Assistant Professor at Case Western University).
April 12th 2016.
Lauren successfully defends her Ph.D. thesis April 12th! Congrats Lauren!
Post-defense celebrations (left to right): Maya Zafrir Springer, Erin Mowers, Lauren Drake, Logan Poole, Casey Kim, Chanelle Robinzine.
Dr. Macleod presents our work at the Banbury meeting on “Autophagy & Cancer” organized by Cold Spring Harbor Laboratories.
Aparajita successfully defends her Ph.D. thesis February 25th! Congrats Aparajita! Good luck in San Diego!
Post-thesis defense celebrations begin! From left to right: Jordan Storber, Logan Poole, Chanelle Robinzine, Erin Mowers, Marina Sharifi (holding baby Aria – Aparajita’s wee one!), Maya Zafrir Springer, Lauren Drake, Aparajita, Dan Rabe (Rosner Lab), Brendan Horton (Gajewski Lab).
Dr. Macleod gives a talk at the Sanford-Burnham-Prebys Medical Discovery Institute entitled: “Autophagy and mitochondrial dysfunction in tumor progression and metastasis”.
Dr. Macleod is quoted in a piece in Nature Methods on how to measure autophagy: http://www.nature.com/nmeth/journal/v12/n12/full/nmeth.3661.html
Dr. Macleod gives a talk at the Simon Cancer Center, Indiana University on “Autophagy in Cell Migration and Metastasis”.
ANSWER CANCER fund-raising video for the University of Chicago Comprehensive Cancer Center: https://www.youtube.com/watch?v=d3vQcE_4-1c&index=1&list=PL97BFD13E72119D89.
As part of October being Breast Cancer Awareness month, Dr. Macleod talks to 5th-8th graders about breast cancer and self-awareness at Ashburn Elementary School! So many great questions from smart young minds!
Our work gets reported in SCIENCELife!
Dr. Macleod is the Keynote Speaker at a symposium on “Mechanisms of Metastasis” at the Huntsman Cancer Institute, University of Utah. Her talk was entitled ” Control of Cell Migration and Metastasis by Autophagy”
Dr. Macleod attends the Banbury Center meeting on “Mitochondria and Cancer” at Cold Spring Harbor Laboratories.
New publication: “Tumor Suppressor Functions of BNip3 and Mitophagy” Autophagy (2015).
August 29th Y-Me Softball Tournament to raise money for breast cancer research
July 21st, Dr. Macleod presents our research at the Cell symposium on “Multifaceted Mitochondria” in Chicago. Her talk was entitled: “BNip3-dependent mitophagy in liver metabolism and responses to nutrient deprivation.”
Aparajita’s paper is accepted into press at EMBO Reports.
July 2nd 10 AM, Michelle Boland successfully defends her Ph.D. thesis! Congratulations Michelle!
Dr. Macleod chairs the major symposium on “Autophagy & Cancer” at the Annual Meeting of the AACR in Philadelphia. Her talk was entitled:”Contrasting consequences of autophagy deficiency and mitophagy deficiency in cancer.” Also speaking in this symposium were Dr. Beth Levine, Dr. Jorge Moscat and Dr. Ravi Amaravadi.
Two new publications:
“Mitophagy & Cancer” Aparajita H. Chourasia, Michelle L. Boland & Kay F. Macleod.
Cancer & Metabolism 3 (4) (2015).
“Measuring autophagy in stressed cells” M.N. Sharifi, E.E. Mowers, L.E. Drake & K. F. Macleod. In “Stress Responses”, Methods in Molecular Biology, vol. 1292, pp129-150, chapter 10 (2015). Ed. Christine E Oslowski. ISBN 978-1-4939-2521-6. Humana Press, Springer Publishing Group.